please add a new term, sinus of lymph node.

[jmfostel]

**Preferred term label: sinus of lymph node
Synonyms lymphatic sinus, lymph node sinus
Definition (free text, please give PubMed ID)
a lymph node sinus consisting of subcapsular, paracortical and medullary sinuses.

i work with pathologists at NIEHS. we have many findings in the lymphatic sinus, and i am looking for a term in UBERON to map these to. i have several pathology findings in the lmphatic sinus and i am looking for an antomy term.

reference 1: Non neoplastic Lesion Atlas, NIEHS: https://ntp.niehs.nih.gov/atlas/nnl
A guide for standardizing terminology in toxicologic pathology for rodents

Lymphatic sinus Ectasia:
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/LymphaticSinusEctasia
Lymphatic sinus ectasia can involve the subcapsular, paracortical, or medullary sinuses of lymph nodes

Sinus Erythrocytosis:
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/SinusErythrocytosis

Reference 2: goRENI

goRENI is the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and at the same time the Internet discussion platform for the global initiative "INHAND" - the International Harmonization of Nomenclature and Diagnostic criteria. https://www.goreni.org/gr3_index.php

Dilatation sinus:
https://www.goreni.org/gr3_diag_text.php?mno=6950&tno=1069
Diffuse or focal dilatation of subcapsular, paracortical, or medullary sinuses.

Erythrocytes, intrasinusoidal:
https://www.goreni.org/gr3_diag_text.php?mno=6206&tno=1069
Erythrocytes are transported to lymph node sinuses via lymphatic drainage from extranodal site of hemorrhage

PubMed:
• PMID: 28955180
refers to the mouse lymphatic sinus in Figure 1.

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon)
lymph node UBERON:0000029

we would request that the current UBERON terms be related, possibly as children. the new term lymphatic sinus is composed of all three:
trabecular sinus of lymph node UBERON:8410032
subcapsular sinus of lymph node UBERON:8410032
lymph node paracortical sinus UBERON:8410074

Your nano-attribution (ORCID) 0000-0001-5858-4393

thank you!

[dosumis]

@dragon-ai-agent please add the requested term as follows:

name: sinus of lymph node
Synonyms: lymphatic sinus, lymph node sinus
Definition: A sinus located in a lymph node. Lymph nodes have subcapsular, cortical/trabacular) and medullary sinuses.
intersection_of: sinus
intersection_of: part_of lymph node

wikipedia is sufficient for refernence: https://en.wikipedia.org/wiki/Lymph_node. make sure you use standard curie pattern to for it.

[dragon-ai-agent]

I have successfully added the requested term for sinus of lymph node.

Term details:

• ID: UBERON:9900001
• Name: sinus of lymph node
• Synonyms: lymphatic sinus, lymph node sinus
• Definition: A sinus located in a lymph node. Lymph nodes have subcapsular, cortical (trabecular) and medullary sinuses.
• Logical definition:
  • intersection_of: UBERON:0000464 (anatomical space)
  • intersection_of: part_of UBERON:0000029 (lymph node)
• Reference: Wikipedia:Lymph_node
• Attribution: Credited to John Fostel (ORCID: 0000-0001-5858-4393)

This term serves as a grouping class for the existing specific lymph node sinus terms:

• UBERON:0005463 (subcapsular sinus of lymph node)
• UBERON:8410032 (trabecular sinus of lymph node)
• UBERON:8410074 (lymph node paracortical sinus)
• UBERON:0009744 (lymph node medullary sinus)

I've created pull request #3621 for review. Please let me know if any adjustments are needed.

@dragon-ai-agent