cochlear nerve root

[dosumis]

Preferred term label:

cochlear nerve root

Synonyms

Definition (free text, please give PubMed ID)

Continuation of the cochlear nerve inside the brain. This is located at the dorsolateral junction of the pons and medulla, entering the brainstem medial to the inferior cerebellar peduncle and restiform body1, 2. Structurally, it forms a wedge-shaped bundle of myelinated fibers that bifurcate upon entry, sending ascending and descending branches into the ventral cochlear nucleus, which it divides into anteroventral and posteroventral regions1, 2. This arrangement enables efficient routing of auditory signals from the cochlea into the brainstem for further processing

https://www.perplexity.ai/search/describe-the-location-structur-ApSlkhThSJStAhbdpJKWFQ

Note - the first sentence is the minimal def. This might be sufficient. Extended, referenced description from Perplexity (see link). Could be dropped if too hard to validate.

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon)

SubClassOf nerve root

part_of brain

Your nano-attribution (ORCID)

[dosumis]

CC @RiveraAndrea83 (I would assign but you need to accept invite first)

[dosumis]

Note: Paper 2 is marsupials, also not open access. Paper 1 is rat. Worry is that the text will be generalised from species-specific descriptions.

[dosumis]

Experimental report on assertion accuracy in Perplexity def Using paper 1 as a ref:

aurelian paperqa ask 'Please break down the following text into a set of independent assertions. Test the validity of each assertion against the literature provided: "The cochlear nerve root in mammals is located at the dorsolateral junction of the pons and medulla, entering the brainstem medial to the inferior cerebellar peduncle and restiform body. Structurally, it forms a wedge-shaped bundle of myelinated fibers that bifurcate upon entry, sending ascending and descending branches into the ventral cochlear nucleus, which it divides into anteroventral and posteroventral regions. This arrangement enables efficient routing of auditory signals from the cochlea into the brainstem for further processing."' -d resources

Note - choosing only one paper might not be a great option here. Also neglected to ask for a results table, which has worked well in other tests.

Details

The following independent assertions can be derived from the provided text:

1. The cochlear nerve root in mammals is located at the dorsolateral junction of the pons and medulla.
2. It enters the brainstem medial to the inferior cerebellar peduncle and restiform body.
3. Structurally, it forms a wedge-shaped bundle of myelinated fibers.
4. Upon entry, the fibers bifurcate, sending ascending and descending branches into the ventral cochlear nucleus.
5. The cochlear nerve root divides the ventral cochlear nucleus into anteroventral and posteroventral regions.
6. This arrangement enables efficient routing of auditory signals from the cochlea into the brainstem for further processing.

Assessment of validity:

1. The location of the cochlear nerve root at the dorsolateral junction of the pons and medulla is supported, as the cochlear nucleus is described as being on the dorsolateral aspect of the rostral medulla, just caudal to the pons (Godfrey2016 pages 2-3, Godfrey2016 pages 16-17, Godfrey2016 pages 17-18).

2. The assertion that the nerve root enters medial to the inferior cerebellar peduncle and restiform body is not directly confirmed; the nucleus is described as superficial to the inferior cerebellar peduncle, but the precise medial relationship is not specified (Godfrey2016 pages 2-3). I cannot answer.

3. The description of the nerve root as a wedge-shaped bundle of myelinated fibers is not addressed in the provided context. I cannot answer.

4. The bifurcation of fibers into ascending and descending branches upon entry is not explicitly described in the provided literature. I cannot answer.

5. The division of the ventral cochlear nucleus into anteroventral and posteroventral regions by the cochlear nerve root is supported; the auditory nerve root (interstitial nucleus) subdivides the ventral cochlear nucleus into anteroventral and posteroventral parts (Godfrey2016 pages 2-3, Godfrey2016 pages 12-13).

6. The functional assertion regarding efficient routing of auditory signals is a general inference and not directly addressed in the provided context. I cannot answer.[/bold blue]
   Answer: The following independent assertions can be derived from the provided text:

7. The cochlear nerve root in mammals is located at the dorsolateral junction of the pons and medulla.

8. It enters the brainstem medial to the inferior cerebellar peduncle and restiform body.

9. Structurally, it forms a wedge-shaped bundle of myelinated fibers.

10. Upon entry, the fibers bifurcate, sending ascending and descending branches into the ventral cochlear nucleus.

11. The cochlear nerve root divides the ventral cochlear nucleus into anteroventral and posteroventral regions.

12. This arrangement enables efficient routing of auditory signals from the cochlea into the brainstem for further processing.

Assessment of validity:

1. The location of the cochlear nerve root at the dorsolateral junction of the pons and medulla is supported, as the cochlear nucleus is described as being on the dorsolateral aspect of the rostral medulla, just caudal to the pons (Godfrey2016 pages 2-3, Godfrey2016 pages 16-17, Godfrey2016 pages 17-18).
2. The assertion that the nerve root enters medial to the inferior cerebellar peduncle and restiform body is not directly confirmed; the nucleus is described as superficial to the inferior cerebellar peduncle, but the precise medial relationship is not specified (Godfrey2016 pages 2-3). I cannot answer.
3. The description of the nerve root as a wedge-shaped bundle of myelinated fibers is not addressed in the provided context. I cannot answer.
4. The bifurcation of fibers into ascending and descending branches upon entry is not explicitly described in the provided literature. I cannot answer.
5. The division of the ventral cochlear nucleus into anteroventral and posteroventral regions by the cochlear nerve root is supported; the auditory nerve root (interstitial nucleus) subdivides the ventral cochlear nucleus into anteroventral and posteroventral parts (Godfrey2016 pages 2-3, Godfrey2016 pages 12-13).
6. The functional assertion regarding efficient routing of auditory signals is a general inference and not directly addressed in the provided context. I cannot answer.

References: 1. (Godfrey2016 pages 2-3): Godfrey, Donald A., Augustine C. Lee, Walter D. Hamilton, Louis C. Benjamin III, Shilpa Vishwanath, Hermann Simo, Lynn M. Godfrey, Abdurrahman I.A.A. Mustapha, and Rickye S. Heffner. "Volumes of Cochlear Nucleus Regions in Rodents." Hearing Research, vol. 339, 2016, pp. 161–174. PubMed Central, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834372/. Accessed 4 Apr. 2025.

2. (Godfrey2016 pages 12-13): Godfrey, Donald A., Augustine C. Lee, Walter D. Hamilton, Louis C. Benjamin III, Shilpa Vishwanath, Hermann Simo, Lynn M. Godfrey, Abdurrahman I.A.A. Mustapha, and Rickye S. Heffner. "Volumes of Cochlear Nucleus Regions in Rodents." Hearing Research, vol. 339, 2016, pp. 161–174. PubMed Central, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834372/. Accessed 4 Apr. 2025.

3. (Godfrey2016 pages 16-17): Godfrey, Donald A., Augustine C. Lee, Walter D. Hamilton, Louis C. Benjamin III, Shilpa Vishwanath, Hermann Simo, Lynn M. Godfrey, Abdurrahman I.A.A. Mustapha, and Rickye S. Heffner. "Volumes of Cochlear Nucleus Regions in Rodents." Hearing Research, vol. 339, 2016, pp. 161–174. PubMed Central, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834372/. Accessed 4 Apr. 2025.

4. (Godfrey2016 pages 17-18): Godfrey, Donald A., Augustine C. Lee, Walter D. Hamilton, Louis C. Benjamin III, Shilpa Vishwanath, Hermann Simo, Lynn M. Godfrey, Abdurrahman I.A.A. Mustapha, and Rickye S. Heffner. "Volumes of Cochlear Nucleus Regions in Rodents." Hearing Research, vol. 339, 2016, pp. 161–174. PubMed Central, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834372/. Accessed 4 Apr. 2025.

[dosumis]

@dragon-ai-agent please add the term, with the definition as requested, but including only assertions validated by the test with Aurelian in the later comment and only references supported by this validation.

[dragon-ai-agent]

✅ Completed: Added cochlear nerve root term

I have successfully added the new term 'cochlear nerve root' (UBERON:7770009) as requested, with a definition based solely on the assertions validated by Aurelian testing.

What was implemented:

• Term ID: UBERON:7770009
• Name: cochlear nerve root
• Definition: "Continuation of the cochlear nerve inside the brain. This is located at the dorsolateral junction of the pons and medulla and divides the ventral cochlear nucleus into anteroventral and posteroventral regions."
• Reference: PMID:27289629 (the Godfrey 2016 paper validated by Aurelian)
• Classification: is_a nerve root, part_of brain

Validation approach:

Following your instruction to include "only assertions validated by the test with Aurelian," I included only the two assertions that were confirmed:

1. ✅ Location at dorsolateral junction of pons and medulla
2. ✅ Division of ventral cochlear nucleus into anteroventral and posteroventral regions

I excluded the unvalidated assertions about nerve structure, fiber bifurcation, and functional aspects that Aurelian could not confirm from the literature.

Pull Request: #3571 - Ready for your review.

@dragon-ai-agent

[dosumis]

After discussion with Andrea, I think a better first sentence might be 'A nerve root that is a continuation of the fibers of the cochlear nerve inside the brain.' If agreed we could change all nerve roots to follow this pattern.

[github-actions]

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